Na Dooro
JDK waxay leedahay tas-hiilaadka wax soo saarka heerka koowaad iyo qalabka maaraynta tayada, kaas oo hubinaya sahayda xasilloon ee dhexdhexaadiyeyaasha API.Kooxda xirfadlayaasha ahi waxay xaqiijinayaan R&D alaabta.Labada dhinacba, waxaan ka raadineynaa CMO & CDMO suuqa gudaha iyo dibadda.
Sharaxaada Alaabta
Xuddunta, 17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid waa xarun adag oo leh karti weyn oo codsiyo kala duwan ah.Qaab-dhismeedkeeda molecular iyo isku-dhafka gaarka ah ee curiyeyaasha ayaa ka dhigaya hanti qiimo leh horumarinta daroogada, biochemistry iyo dadaallada sayniska ee la xidhiidha.
Mid ka mid ah sifooyinka ugu muhiimsan ee alaabtan waa kala duwanaansho.17-Amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid waxaa loo isticmaali karaa dhismo dhisme ah oo ka mid ah unugyada bioactive ee kala duwan, sida peptides iyo borotiinnada.Kooxaheeda shaqaynaysa iyo taxanaha amino acid waxay awood u siinayaan wax ka beddel hufan oo sax ah, hubinta heer sare oo xakameyn ah iyo gaar ahaan naqshadeynta daroogada.
Cilmi-baarayaasha iyo saynisyahannada dhinacyada daawada iyo daawaynta ayaa si weyn uga faa'iidaysan doona ku darista badeecadan cilmi-baaristooda.Codsiyada suurtagalka ah waxay u dhexeeyaan nidaamyada gudbinta daroogada ee la beegsaday ilaa horumarinta wakiilada daweynta cusub.Iyada oo la adeegsanayo sifooyinka gaarka ah ee 17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid, shirkadaha dawooyinka ayaa hal-abuuri kara oo abuuri kara daaweyn horudhac ah oo loogu talagalay cudurro kala duwan.
Intaa waxaa dheer, adkaanta alaabtu waxay hubisaa xasilloonida iyo isku halaynta xaaladaha kala duwan ee tijaabada ah.Miisaankeeda kelli iyo qaabaynta ayaa si taxadar leh loogu qaabeeyey si ay u bixiso milanka ugu fiican, taas oo u oggolaanaysa in si fudud loogu dhexgalo borotokool tijaabo ah.Intaa waxaa dheer, daahirsanaanta iyo joogteynta badeecada ayaa dammaanad qaadaya natiijooyinka dib loo soo saari karo, taasoo ka dhigaysa qalab aan looga maarmin natiijooyinka cilmi-baarista la isku halayn karo.
Marka ay timaado dhanka badbaadada, waxaan qaadnaa taxadar kasta si aan u hubinno in 17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid ay buuxiso heerarka tayada ugu sarreeya.Tallaabooyinka xakamaynta tayada adag ayaa la qaadaa inta lagu guda jiro habka wax soo saarka si loo hubiyo maqnaanshaha wax wasakh ah ama wasakhaysan.
![Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid iyo (3R, 4R) - N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8](http://cdn.globalso.com/jdkhc/2R-3R-23-bis-4-methylbenzoyl-oxy-succinic-acid-and-3R-4R-N-4-dimethyl-1-phenylmethyl-3-piperidine-amine.jpg)
